GRK2243 Symposium
Understanding Ubiquitylation:
From Molecular Mechanisms to Disease
9-11 May 2022 I Würzburg, Germany
The Meeting
The post-translational modification of proteins with ubiquitin ("ubiquitylation") has taken center stage in eukaryotic cell biology. Ubiquitylation mediates the degradation of regulatory and damaged proteins, protein aggregates and even entire organelles. Moreover, it controls a wide variety of non-proteolytic processes, e.g. during DNA damage repair, receptor signaling and endocytosis.
Given the multi-faceted cellular functions of protein ubiquitylation, it is not surprising that abnormalities of the ubiquitin system lead to many human diseases including cancer, neurodegenerative disorders and infectious diseases. Moreover, the ubiquitin system has emerged as a promising target for therapeutic intervention, and drugs interfering with ubiquitin-mediated proteolysis are successfully used for the treatment of certain cancers.
This Symposium aims to showcase the most recent, exciting progress towards understanding molecular mechanisms, cellular functions and pathogenic aberrations of the ubiquitin system as well as developing novel therapeutic strategies targeting it. The meeting will feature cutting-edge research presentations by international leaders in the field, additional short talks selected from submitted abstracts, and a large poster session along with poster teasers. There will be ample opportunity for scientific interactions between all participants to stimulate further progress in ubiquitin research.
GRK2243
The Symposium is organized by the Research Training Group GRK2243, a ubiquitin-themed graduate program, which has been funded by the German Research Foundation DFG since April 2017. The GRK2243 offers cutting-edge research projects and a structured, interdisciplinary training program for more than 30 PhD students and postdocs at the University of Würzburg.
For further information, please visit our webpage:
REGISTRATION DEADLINE
1 February 2022
ABSTRACT SUBMISSION
DEADLINE
15 March 2022
Short talks will be selected from abstracts.
Find us on Twitter:
@grk2243
#wUeBI2022
Speakers
For further information, please click on the speakers’ portraits.
Program
Day 1 - 9 May 2022
1.00 - 2.00 pm Arrival and registration
2.00 pm Welcome address
2.10 - 3.50 pm Session 1: Ubiquitin–DNA transactions
Keynote: Cynthia Wolberger - Histone H2B ubiquitination in transcription regulation
Karim Labib - Destroying the eukaryotic replisome
Daniel Solvie - Ubiquitin-driven condensation of MYC oncoproteins
Maximilian Fottner - A modular toolbox to generate complex polymeric ubiquitin
architectures using orthogonal sortase enzymes
3.50 - 4.30 pm Coffee break
4.30 - 6.05 pm Session 2: Signaling
Bruce Clurman - Tumor suppression by the Fbw7 ubiquitin ligase: Myc and beyond
Anna Sablina - The ubiquitin system in RAS-driven disease
Uta Demel - Activated SUMOylation restricts MHC class I antigen presentation to confer
immune evasion in cancer
Michael Adams - Structural basis for protein glutamylation by the Legionella
pseudokinase SidJ
6.15 - 7.00 pm Poster power show (1 min teaser presentations)
7.00 - 10.00 pm Poster session
& Finger food dinner
Day 2 - 10 May 2022
9.00 - 10.30 am Session 3: (De-)Ubiquitylating enzymes
Brenda Schulman - Regulation of and by cullin-RING E3 ubiquitin ligases
Rachel Klevit - Substrate recognition by RING-Between-RING E3s
Gisela Otten - Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
Yogesh Kulathu - Insights into UFMylation: the neglected but essential
ubiquitin-like modifier
10.30 - 11.00 am Coffee break
11.00 - 12.30 pm Session 3 ctd.: (De-)Ubiquitylating enzymes
Titia Sixma - Allosteric regulation of DUB activity
Sylvie Urbé - Deubiquitylases: druggable regulators of protein and organelle
homeostasis
Malte Gersch - Structural basis for specific inhibition of the deubiquitinase UCHL1
Thomas Hermanns - A family of linkage-specific ubiquitin C-terminal clippases
12.30 - 2.00 pm Lunch
2.00 - 4.15 pm Session 4: Tool and drug development
Keynote: Craig Crews - PROTAC-mediated protein degradation:
A new therapeutic modality
Nicolas Thomä - Haven’t got a glue: mechanistic dissection of small molecular
glue degraders
Helle Ulrich - Ubiquiton – an inducible, linkage-selective ubiquitylation tool
Anne Bertolotti - Boosting protein quality control: A strategy against
neurodegenerative diseases
Bianca van Tol - Development of neutron-encoded ubiquitin chains to study
deubiquitinase activity in presence of all eight ubiquitin linkages
4.15 - 5.00 pm Coffee break
5.00 - 7.00 pm Leisure time to enjoy Würzburg
7.00 pm Conference dinner at Bürgerspital
Day 3 - 11 May 2022
9.00 - 10.50 am Session 5: Proteostasis
Keynote: Ivan Đikic - Ubiquitin signalling and ER remodelling
Hemmo Meyer - Control of lysophagy by ubiquitination
Anja Bremm - USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
Melissa Hoyer - Organelle quality control in neuronal cells
10.50 - 11.20 am Coffee break
11.20 - 1.00 pm Session 5 ctd.: Proteostasis
Thorsten Hoppe - The ubiquitin ligase CHIP Is regulated by a molecular switch
mechanism in proteostasis and aging
Jesper Svejstrup - The last resort pathway for contending with transcription-
obstructing DNA damage
Elke Krüger - Rare proteasomopathies: Unraveling the role of the ubiquitin proteasome system in innate immune signaling
Andreas Martin - “Say aah”: Ubiquitin chains allosterically regulate substrate entry
into the 26S proteasome
1.00 pm Closing remarks
Lunch (packed)
Departure
Registration & Fees
REGISTRATION DEADLINE
1 February 2022
ABSTRACT SUBMISSON DEADLINE
15 March 2022
Registration fees
PhD student, Postdoc 100 €
Academic 150 €
Industry 250 €
Registration includes:
-
Conference materials
-
Access to all sessions
-
Conference dinner at Bürgerspital
-
Food and drinks during coffee breaks, lunches and finger food during poster session
Accommodation is not included. Please see hotel registration information under LOCATION below.
Payment
Please note that payment must be submitted only after receipt of confirmation that your registration has been accepted. At that point, you will receive an email from the organizers with detailed payment instructions. Payment ought to be made via national and international bank transfer exclusively. Credit card payment is not possible.
Cancellation and registration fee refund policy:
-
Notification of cancellation should be made in writing and sent to the conference organizers:
ubiquitin2022@uni-wuerzburg.de
-
100% refund (less 25 € handling fee) if a notification e-mail reaches the organizers on or before
15 March 2022.
-
No refund on cancellations after 15 March 2022.
Selection criteria
The admission of participants (in case of overbooking) will be guided by the submitted abstracts, according to the expected scientific impact of the work on the conference and the field. It is thus recommended that all participants submit an abstract at the time of registration and specify whether they wish to present a poster or short talk.
For participants who do not plan to present their work, a CV (for principal investigators) or motivation letter (for students/post-docs) is requested.
Abstract guidelines
Please download the abstract template and follow the instructions therein.
Poster specifications
Please bring one printed copy of your poster in portrait orientation (not landscape).
POSTERS SHOULD HAVE A SIZE OF DIN A0 (84,1 x 118,9 cm).
Short talks
A number of short talks (10 min talk followed by 5 min discussion) – preferentially by early-career scientists – will be selected from the submitted abstracts ahead of the meeting.
Please indicate whether you would like to be considered for a short talk at the time of registration. Applicants will be notified at least three weeks before the meeting.
Contact
Organizing committee
Alexander Buchberger
Biocenter, University of Würzburg
Caroline Kisker
Rudolf Virchow Center, University of Würzburg
Hermann Schindelin
Rudolf Virchow Center, University of Würzburg
Elmar Wolf
Biocenter, University of Würzburg
Bikash Adhikari
Biocenter, University of Würzburg
Pranjali Bhandare
Biocenter, University of Würzburg
Sophie Hügelschäffer
Biocenter, University of Würzburg
Jonathan Patzke
Rudolf Virchow Center, University of Würzburg
Location
Meeting Venue
Congress Center Würzburg
Pleichertorstraße
97070 Würzburg
Germany
For further information, please check:
www.wuerzburg.de/tourismus/tagungen-kongresse/tagung/besucher/index.html
(German website only)
City of Würzburg
Arrival and parking at the Congress Centrum
By car: Please enter the destination "Pleichertorstraße" in the navigation system. There are several parking lots in the immediate vicinity of the Congress Centrum: (I) the Congress Centrum underground parking at Pleichertorstraße (246 slots), (II) Congress Centrum parking lot at the Kranenkai (60 slots), and (III) Talavera parking lot (1000 free parking spaces on the other side of the river Main, 5-minute walk from the Congress Centrum).
By public transport: From the main train station, you can reach the Congress Centrum by tramway line 2 to "Zellerau", stop "Congress Centrum".
By foot: From the main train station walk towards the river Main and either follow the street "Röntgenring" or walk through the Ringpark, about 10 minutes walk.
Accommodation
Please note that accommodation is not included in the registration fee and has to be organized by the participants on their own.
For the three nights, May 8-11, 2022, participants are offered rooms at the Maritim Hotel (incl. breakfast) which is directly located at the Congress Center: single room comfort for 129 €/per night and double room comfort for 169 €/per night. Please make your reservation directly with the hotel, using code GRK2243. A limited number of rooms have been reserved for the conference and will be available on a first-come-first-serve basis until March 25, 2022.
For budget hotels, we recommend Ibis or B&B Hotel in Veitshöchheimer Straße, which are in walking distance to the conference venue.
For further accommodation opportunities, please check here:
www.wuerzburg.de/tourismus/unterkunft-buchen/hotels-pensionen/index.html
About Würzburg
For further information, please check the official tourist information website of Würzburg:
Copyright: Peter Schumann (cover image, www.dasistwuerzburg.de), Congress-Tourismus-Würzburg & Katrin Heyer