GRK2243 Symposium

Understanding Ubiquitylation:

From Molecular Mechanisms to Disease

9-11 May 2022 I Würzburg, Germany 

 

The Meeting

The post-translational modification of proteins with ubiquitin ("ubiquitylation") has taken center stage in eukaryotic cell biology. Ubiquitylation mediates the degradation of regulatory and damaged proteins, protein aggregates and even entire organelles. Moreover, it controls a wide variety of non-proteolytic processes, e.g. during DNA damage repair, receptor signaling and endocytosis.

 

Given the multi-faceted cellular functions of protein ubiquitylation, it is not surprising that abnormalities of the ubiquitin system lead to many human diseases including cancer, neurodegenerative disorders and infectious diseases. Moreover, the ubiquitin system has emerged as a promising target for therapeutic intervention, and drugs interfering with ubiquitin-mediated proteolysis are successfully used for the treatment of certain cancers. 

 

This Symposium aims to showcase the most recent, exciting progress towards understanding molecular mechanisms, cellular functions and pathogenic aberrations of the ubiquitin system as well as developing novel therapeutic strategies targeting it. The meeting will feature cutting-edge research presentations by international leaders in the field, additional short talks selected from submitted abstracts, and a large poster session along with poster teasers. There will be ample opportunity for scientific interactions between all participants to stimulate further progress in ubiquitin research.

GRK2243

The Symposium is organized by the Research Training Group GRK2243, a ubiquitin-themed graduate program, which has been funded by the German Research Foundation DFG since April 2017. The GRK2243 offers cutting-edge research projects and a structured, interdisciplinary training program for more than 30 PhD students and postdocs at the University of Würzburg.

For further information, please visit our webpage: 

www.uni-wuerzburg.de/grk2243

REGISTRATION DEADLINE

1 February 2022

ABSTRACT SUBMISSION

DEADLINE

15 March 2022

Short talks will be selected from abstracts.

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Program

Day 1 - 9 May 2022

 1.00 - 2.00 pm      Arrival and registration

           2.00 pm      Welcome address

 2.10 - 3.50 pm      Session 1: Ubiquitin–DNA transactions

                           KeynoteCynthia Wolberger - Histone H2B ubiquitination in transcription regulation

                           Karim Labib - Destroying the eukaryotic replisome

                               Daniel Solvie - Ubiquitin-driven condensation of MYC oncoproteins

                               Maximilian Fottner - A modular toolbox to generate complex polymeric ubiquitin
                                                                     architectures using orthogonal sortase enzymes

 3.50 - 4.30 pm      Coffee break

 4.30 - 6.05 pm      Session 2: Signaling

                           Bruce Clurman - Tumor suppression by the Fbw7 ubiquitin ligase: Myc and beyond

                           Anna Sablina - The ubiquitin system in RAS-driven disease 

                           Uta Demel - Activated SUMOylation restricts MHC class I antigen presentation to confer
                                                      immune evasion in cancer

                           Michael Adams - Structural basis for protein glutamylation by the Legionella
                                                             
pseudokinase SidJ   

 6.15 - 7.00 pm      Poster power show (1 min teaser presentations)

 7.00 - 10.00 pm    Poster session

                           & Finger food dinner

Day 2 - 10 May 2022

 9.00 - 10.30 am    Session 3: (De-)Ubiquitylating enzymes

                           Brenda Schulman - Regulation of and by cullin-RING E3 ubiquitin ligases

                           Rachel Klevit - Substrate recognition by RING-Between-RING E3s

                           Gisela Otten - Ubiquitylation of lipopolysaccharide by RNF213 during bacterial                                                                  infection

                               Yogesh Kulathu - Insights into UFMylation: the neglected but essential
                                                               ubiquitin-like modifier

10.30 - 11.00 am   Coffee break

11.00 - 12.30 pm   Session 3 ctd.: (De-)Ubiquitylating enzymes

                           Titia Sixma - Allosteric regulation of DUB activity

                           Sylvie Urbé - Deubiquitylases: druggable regulators of protein and organelle
                                                        homeostasis

                           Malte Gersch - Structural basis for specific inhibition of the deubiquitinase UCHL1 

                           Thomas Hermanns - A family of linkage-specific ubiquitin C-terminal clippases 

 12.30 - 2.00 pm     Lunch

 2.00 - 4.15 pm      Session 4: Tool and drug development

                           Keynote: Craig Crews - PROTAC-mediated protein degradation:
                                                                          A new therapeutic modality

                           Nicolas Thomä - Haven’t got a glue: mechanistic dissection of small molecular
                                                              glue degraders

                           Helle Ulrich  - Ubiquiton – an inducible, linkage-selective ubiquitylation tool

                           Anne Bertolotti - Boosting protein quality control: A strategy against
                                                              neurodegenerative diseases

                               Bianca van Tol - Development of neutron-encoded ubiquitin chains to study
                                                            deubiquitinase activity in presence of all eight ubiquitin linkages
 

      

 4.15 - 5.00 pm      Coffee break

 5.00 - 7.00 pm      Leisure time to enjoy Würzburg

 7.00 pm                Conference dinner at Bürgerspital                           

Day 3 - 11 May 2022

 9.00 - 10.50 am    Session 5: Proteostasis

                           Keynote:  Ivan Đikic - Ubiquitin signalling and ER remodelling

                           Hemmo Meyer - Control of lysophagy by ubiquitination

                           Anja Bremm - USP32-regulated LAMTOR1 ubiquitination impacts mTORC1                                                                       activation and autophagy induction

                           Melissa Hoyer - Organelle quality control in neuronal cells

10.50 - 11.20 am   Coffee break

11.20 - 1.00 pm     Session 5 ctd.: Proteostasis

     Thorsten Hoppe - The ubiquitin ligase CHIP Is regulated by a molecular switch
                                        mechanism in proteostasis and aging

                           Jesper Svejstrup - The last resort pathway for contending with transcription-
                                                                obstructing DNA damage

                           Elke Krüger - Rare proteasomopathies: Unraveling the role of the ubiquitin                                                                        proteasome system in innate immune signaling

                           Andreas Martin - “Say aah”: Ubiquitin chains allosterically regulate substrate entry
                                                                into the 26S proteasome

                           

 1.00 pm                Closing remarks

                           Lunch (packed)

                               Departure

 

Registration & Fees

REGISTRATION DEADLINE

1 February 2022

ABSTRACT SUBMISSON DEADLINE

15 March 2022

Registration fees

PhD student, Postdoc                      100 €

Academic                                          150 €

Industry                                             250 €

Online Application

Registration includes:

  • Conference materials

  • Access to all sessions

  • Conference dinner at Bürgerspital

  • Food and drinks during coffee breaks, lunches and finger food during poster session

 

Accommodation is not included. Please see hotel registration information under LOCATION below.

Payment

Please note that payment must be submitted only after receipt of confirmation that your registration has been accepted. At that point, you will receive an email from the organizers with detailed payment instructions. Payment ought to be made via national and international bank transfer exclusively. Credit card payment is not possible.

 

Cancellation and registration fee refund policy:

  1. Notification of cancellation should be made in writing and sent to the conference organizers: 
    ubiquitin2022@uni-wuerzburg.de
     

  2. 100% refund (less 25 € handling fee) if a notification e-mail reaches the organizers on or before
    15 March 2022.
     

  3. No refund on cancellations after 15 March 2022.

Selection criteria

The admission of participants (in case of overbooking) will be guided by the submitted abstracts, according to the expected scientific impact of the work on the conference and the field. It is thus recommended that all participants submit an abstract at the time of registration and specify whether they wish to present a poster or short talk.

 

For participants who do not plan to present their work, a CV (for principal investigators) or motivation letter (for students/post-docs) is requested.

Abstract guidelines

 

Please download the abstract template and follow the instructions therein. 

Poster specifications

 

Please bring one printed copy of your poster in portrait orientation (not landscape). 

POSTERS SHOULD HAVE A SIZE OF DIN A0 (84,1 x 118,9 cm).

Short talks

 

A number of short talks (10 min talk followed by 5 min discussion) – preferentially by early-career scientists – will be selected from the submitted abstracts ahead of the meeting.

Please indicate whether you would like to be considered for a short talk at the time of registration. Applicants will be notified at least three weeks before the meeting.

 
Contact

Coordinator GRK2243: Julia Seubert 

Email: ubiquitin2022@uni-wuerzburg.de

 

Organizing committee

Alexander Buchberger

Biocenter, University of Würzburg

Caroline Kisker

Rudolf Virchow Center, University of Würzburg

Hermann Schindelin

Rudolf Virchow Center, University of Würzburg

Elmar Wolf

Biocenter, University of Würzburg

Bikash Adhikari 

Biocenter, University of Würzburg

Pranjali Bhandare

Biocenter, University of Würzburg

Sophie Hügelschäffer

Biocenter, University of Würzburg

Jonathan Patzke

Rudolf Virchow Center, University of Würzburg

Location

Meeting Venue

Congress Center Würzburg

Pleichertorstraße

97070 Würzburg

Germany

For further information, please check:

www.wuerzburg.de/tourismus/tagungen-kongresse/tagung/besucher/index.html

(German website only)

441301_congress_centrum_aussen.jpg

City of Würzburg

Arrival and parking at the Congress Centrum

By car: Please enter the destination "Pleichertorstraße" in the navigation system. There are several parking lots in the immediate vicinity of the Congress Centrum: (I) the Congress Centrum underground parking at Pleichertorstraße (246 slots), (II) Congress Centrum parking lot at the Kranenkai (60 slots), and (III) Talavera parking lot (1000 free parking spaces on the other side of the river Main, 5-minute walk from the Congress Centrum).

 

By public transport: From the main train station, you can reach the Congress Centrum by tramway line 2 to "Zellerau", stop "Congress Centrum".

 

By foot: From the main train station walk towards the river Main and either follow the street "Röntgenring" or walk through the Ringpark, about 10 minutes walk.

Accommodation

Please note that accommodation is not included in the registration fee and has to be organized by the participants on their own.

For the three nights, May 8-11, 2022, participants are offered rooms at the Maritim Hotel (incl. breakfast) which is directly located at the Congress Center: single room comfort for 129 €/per night and double room comfort for 169 €/per night. Please make your reservation directly with the hotel, using code GRK2243. A limited number of rooms have been reserved for the conference and will be available on a first-come-first-serve basis until March 25, 2022.

 

For budget hotels, we recommend Ibis or B&B Hotel in Veitshöchheimer Straße, which are in walking distance to the conference venue.

 

For further accommodation opportunities, please check here:

www.wuerzburg.de/tourismus/unterkunft-buchen/hotels-pensionen/index.html

About Würzburg

For further information, please check the official tourist information website of Würzburg:

www.wuerzburg.de/en/visitors/index.html

Copyright: Peter Schumann (cover image, www.dasistwuerzburg.de), Congress-Tourismus-Würzburg & Katrin Heyer

 

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