GRK2243 Symposium on Ubiquitin 2022

GRK2243 Symposium

Understanding Ubiquitylation:

From Molecular Mechanisms to Disease

9-11 May 2022 I Würzburg, Germany

The Meeting

The post-translational modification of proteins with ubiquitin ("ubiquitylation") has taken center stage in eukaryotic cell biology. Ubiquitylation mediates the degradation of regulatory and damaged proteins, protein aggregates and even entire organelles. Moreover, it controls a wide variety of non-proteolytic processes, e.g. during DNA damage repair, receptor signaling and endocytosis.

Given the multi-faceted cellular functions of protein ubiquitylation, it is not surprising that abnormalities of the ubiquitin system lead to many human diseases including cancer, neurodegenerative disorders and infectious diseases. Moreover, the ubiquitin system has emerged as a promising target for therapeutic intervention, and drugs interfering with ubiquitin-mediated proteolysis are successfully used for the treatment of certain cancers.

This Symposium aims to showcase the most recent, exciting progress towards understanding molecular mechanisms, cellular functions and pathogenic aberrations of the ubiquitin system as well as developing novel therapeutic strategies targeting it. The meeting will feature cutting-edge research presentations by international leaders in the field, additional short talks selected from submitted abstracts, and a large poster session along with poster teasers. There will be ample opportunity for scientific interactions between all participants to stimulate further progress in ubiquitin research.

GRK2243

The Symposium is organized by the Research Training Group GRK2243, a ubiquitin-themed graduate program, which has been funded by the German Research Foundation DFG since April 2017. The GRK2243 offers cutting-edge research projects and a structured, interdisciplinary training program for more than 30 PhD students and postdocs at the University of Würzburg.

For further information, please visit our webpage:

www.uni-wuerzburg.de/grk2243

Program

REGISTRATION DEADLINE

1 February 2022

ABSTRACT SUBMISSION

DEADLINE

15 March 2022

Short talks will be selected from abstracts.

Find us on Twitter:
@grk2243

#wUeBI2022

Apply now!

DOWNLOAD
POSTER

Speakers

For further information, please click on the speakers’ portraits.

Program

Day 1 - 9 May 2022

1.00 - 2.00 pm Arrival and registration

2.00 pm Welcome address

2.10 - 3.50 pm Session 1: Ubiquitin–DNA transactions

Keynote: Cynthia Wolberger - Histone H2B ubiquitination in transcription regulation

Karim Labib - Destroying the eukaryotic replisome

Daniel Solvie - Ubiquitin-driven condensation of MYC oncoproteins

Maximilian Fottner - A modular toolbox to generate complex polymeric ubiquitin
architectures using orthogonal sortase enzymes

3.50 - 4.30 pm Coffee break

4.30 - 6.05 pm Session 2: Signaling

Bruce Clurman - Tumor suppression by the Fbw7 ubiquitin ligase: Myc and beyond

Anna Sablina - The ubiquitin system in RAS-driven disease

Uta Demel - Activated SUMOylation restricts MHC class I antigen presentation to confer
immune evasion in cancer

Michael Adams - Structural basis for protein glutamylation by the Legionella
pseudokinase SidJ

6.15 - 7.00 pm Poster power show (1 min teaser presentations)

7.00 - 10.00 pm Poster session

& Finger food dinner

Day 2 - 10 May 2022

9.00 - 10.30 am Session 3: (De-)Ubiquitylating enzymes

Brenda Schulman - Regulation of and by cullin-RING E3 ubiquitin ligases

Rachel Klevit - Substrate recognition by RING-Between-RING E3s

Gisela Otten - Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

Yogesh Kulathu - Insights into UFMylation: the neglected but essential
ubiquitin-like modifier

10.30 - 11.00 am Coffee break

11.00 - 12.30 pm Session 3 ctd.: (De-)Ubiquitylating enzymes

Titia Sixma - Allosteric regulation of DUB activity

Sylvie Urbé - Deubiquitylases: druggable regulators of protein and organelle
homeostasis

Malte Gersch - Structural basis for specific inhibition of the deubiquitinase UCHL1

Thomas Hermanns - A family of linkage-specific ubiquitin C-terminal clippases

12.30 - 2.00 pm Lunch

2.00 - 4.15 pm Session 4: Tool and drug development

Keynote: Craig Crews - PROTAC-mediated protein degradation:
A new therapeutic modality

Nicolas Thomä - Haven’t got a glue: mechanistic dissection of small molecular
glue degraders

Helle Ulrich - Ubiquiton – an inducible, linkage-selective ubiquitylation tool

Anne Bertolotti - Boosting protein quality control: A strategy against
neurodegenerative diseases

Bianca van Tol - Development of neutron-encoded ubiquitin chains to study
deubiquitinase activity in presence of all eight ubiquitin linkages

4.15 - 5.00 pm Coffee break

5.00 - 7.00 pm Leisure time to enjoy Würzburg

7.00 pm Conference dinner at Bürgerspital

Day 3 - 11 May 2022

9.00 - 10.50 am Session 5: Proteostasis

Keynote: Ivan Đikic - Ubiquitin signalling and ER remodelling

Hemmo Meyer - Control of lysophagy by ubiquitination

Anja Bremm - USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

Melissa Hoyer - Organelle quality control in neuronal cells

10.50 - 11.20 am Coffee break

11.20 - 1.00 pm Session 5 ctd.: Proteostasis

Thorsten Hoppe - The ubiquitin ligase CHIP Is regulated by a molecular switch
mechanism in proteostasis and aging

Jesper Svejstrup - The last resort pathway for contending with transcription-
obstructing DNA damage

Elke Krüger - Rare proteasomopathies: Unraveling the role of the ubiquitin proteasome system in innate immune signaling

Andreas Martin - “Say aah”: Ubiquitin chains allosterically regulate substrate entry
into the 26S proteasome

1.00 pm Closing remarks

Lunch (packed)

Departure

Program

Registration & Fees

REGISTRATION DEADLINE

1 February 2022

ABSTRACT SUBMISSON DEADLINE

15 March 2022

Registration fees

PhD student, Postdoc 100 €

Academic 150 €

Industry 250 €

Online Application

Registration includes:

Conference materials
Access to all sessions
Conference dinner at Bürgerspital
Food and drinks during coffee breaks, lunches and finger food during poster session

Accommodation is not included. Please see hotel registration information under LOCATION below.

Payment

Please note that payment must be submitted only after receipt of confirmation that your registration has been accepted. At that point, you will receive an email from the organizers with detailed payment instructions. Payment ought to be made via national and international bank transfer exclusively. Credit card payment is not possible.

Cancellation and registration fee refund policy:

Notification of cancellation should be made in writing and sent to the conference organizers:
ubiquitin2022@uni-wuerzburg.de
100% refund (less 25 € handling fee) if a notification e-mail reaches the organizers on or before
15 March 2022.
No refund on cancellations after 15 March 2022.

Selection criteria

The admission of participants (in case of overbooking) will be guided by the submitted abstracts, according to the expected scientific impact of the work on the conference and the field. It is thus recommended that all participants submit an abstract at the time of registration and specify whether they wish to present a poster or short talk.

For participants who do not plan to present their work, a CV (for principal investigators) or motivation letter (for students/post-docs) is requested.

Abstract guidelines

Please download the abstract template and follow the instructions therein.

Abstract template

Poster specifications

Please bring one printed copy of your poster in portrait orientation (not landscape).

POSTERS SHOULD HAVE A SIZE OF DIN A0 (84,1 x 118,9 cm).

Short talks

A number of short talks (10 min talk followed by 5 min discussion) – preferentially by early-career scientists – will be selected from the submitted abstracts ahead of the meeting.

Please indicate whether you would like to be considered for a short talk at the time of registration. Applicants will be notified at least three weeks before the meeting.

Registration & Fees

Contact

Coordinator GRK2243: Julia Seubert

Email: ubiquitin2022@uni-wuerzburg.de

Contact